CASE STUDY
Digital Microfluidics
When Roche needed help with designing a platform-based testing cartridge, we lead the way.
THE PROBLEM
In the realm of diagnostics, there existed a critical challenge—efficient small-volume fluid handling within a digital microfluidic system. Traditional approaches were falling short, hindering the advancement of rapid, multiplex molecular diagnostics. The need for a groundbreaking solution to optimize fluid manipulation was evident.
THE SOLUTION
Recognizing the urgency and potential impact, our team collaborated closely with the team at Roche, a leader in the world of biotechnology. The objective was clear: design an innovative microfluidic cartridge that seamlessly integrates EWOD, enabling precise small-volume fluid handling to efficiently run diagnostic tests.
KEY ELEMENTS
1
Electrowetting-on-Dielectric (EWOD) Integration
Phase Three’s expertise in EWOD technology played a pivotal role. The microfluidic cartridge was meticulously designed to leverage EWOD principles, allowing for dynamic control of fluid droplets on the cartridge surface.
2
Biochemical Expertise in Reaction Orchestration
To enhance the diagnostic process, Phase Three brought biochemical expertise to orchestrate how the sample interacts with the proper reagents. This critical step ensured optimal reactions within the microfluidic cartridge, contributing to the accuracy and reliability of the diagnostic results.
3
Intelligent Reading and Interpretation
The collaborative effort introduced intelligent reading and interpretation capabilities to the microfluidic cartridge. This advanced feature allows for the accurate and rapid interpretation of diagnostic results, providing clinicians with a dependable testing solution.
4
Seamless Component Selection and Assembly
Finding the right materials and putting it all together in a product prototype is our forte. This streamlined getting the product to market efficiently.
Cartridge options included both gram-positive and gram-negative bacteria, fungal pathogens and more.
Revolutionizing Diagnostics with Innovative Microfluidic Cartridge Design
a.) GenMark/Roche ePlex Analyzer, b.) ePlex diagnostic cartridge, c.) internal cartridge components
THE OUTCOMES
The collaborative solution redefined the landscape of molecular diagnostics. The innovative microfluidic cartridge, born out of the partnership with Phase Three, has demonstrated unparalleled precision, efficiency, and versatility. Its successful integration of digital microfluidics, biochemical expertise, intelligent sample reading and interpretation has positioned it as a transformative tool in the field of diagnostics.
THE PARTNERSHIP
The success of this collaborative venture is a testament to the quality of Phase Three’s work. Potential partners and clients seeking cutting-edge solutions in microfluidics have come to the right place. Our deep expertise in the handling of small fluid samples is unmatched and we’d love to help you with your next big project. Together, we can lead the way in advancing patient care.
STARTING WITH YOUR INSPIRATION
Phase Three Product Development (P3PD) has simplified the product development process in the life science and medical device industries.
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