CASE STUDY
Cell Sorting
Phase Three Supercharged the Development of Cytonome’s Next Generation Cell Sorting Technology
THE PROBLEM
Cytonome aimed to advance its technology for high-speed cell sorting and bioprocessing, specifically focusing on optimizing the microfluidics chip design. The challenges included improving sorting efficiency, maintaining cell viability, and ensuring compliance with cGMP requirements. Cytonome recognized the need for external expertise to achieve these objectives.
THE SOLUTION
In a strategic collaboration, Cytonome partnered with us to leverage our expertise in optimizing and refining cutting-edge technologies. The collaboration involved an in-depth analysis of Cytonome’s existing microfluidics chip design. Phase Three utilized a combination of innovative design ideas, Computational Fluid Dynamics (CFD), prototyping, and rigorous testing to refine and optimize the microfluidics chip.
KEY ELEMENTS
1
Innovative Consumable Design
Phase Three introduced new and innovative design concepts to enhance the performance of Cytonome’s microfluidics chip.
2
Computational Fluid Dynamics (CFD)
Leveraging CFD, Phase Three conducted detailed simulations to analyze fluid flow, optimize channel geometries, and improve sorting efficiency.
3
Prototyping and Testing
The team at Phase Three developed prototypes based on the optimized design and conducted thorough testing to validate the improvements in sorting speed, cell viability, and overall system performance.
Cytonome’s 24-channel microfluidic chip featuring an enclosed, gamma irradiated fluidics set containing the chip and vessels for sample, sheath, sorted cells and waste
Empowering advanced solutions in cell purification and processing.
THE OUTCOMES
The collaborative efforts between Phase Three and the Cytonome were game changing for the company. The microfluidics chip design was refined, leading to improved sorting efficiency and increased throughput. The optimized design also contributed to higher cell viability, ensuring the integrity of sorted cell populations while meeting the cGMP requirements. All together, Cytonome experienced a threefold increase in intellectual property, solidifying its position as an industry leader and have emerged as one of the fastest-growing company in their vertical.
THE PARTNERSHIP
Phase Three’s instrumental role in the success of Cytonome’s project positions us as an invaluable partner for organizations seeking innovative solutions in biotech. The demonstrated expertise in small volume sample handling, microfluidic cartridge design, and biological systems makes Phase Three an ideal collaborator for those aiming to revolutionize their approach to product development.
STARTING WITH YOUR INSPIRATION
Phase Three Product Development (P3PD) has simplified the product development process in the life science and medical device industries.
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